Therapy flags DNA typos to rev cancer-fighting T cells
Mutations that prevent cells from spell-checking their DNA may make cancer cells vulnerable to immunotherapies, a new study suggests.
A type of immune therapy known as PD-1 blockade controlled cancer in 77 percent of patients with defects in DNA mismatch repair — the system cells use to spell-check and fix errors in DNA. The therapy was effective against 12 different types of solid tumors, including colorectal, gastroesophageal and pancreatic cancers, and even tumors of unknown origin, researchers report June 8 in Science. Read more.